DJ-1 is an essential downstream mediator in PINK1/parkin-dependent mitophagy

Loss-of-function mutations in the PRKN, PINK1 and PARK7 genes (encoding parkin, PINK1 and DJ-1, respectively) cause autosomal recessive forms of Parkinson’s disease. PINK1 and parkin jointly mediate selective autophagy of damaged mitochondria (mitophagy), but the mechanisms by which loss of DJ-1 ind...

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Detalles Bibliográficos
Autores principales: Imberechts, Dorien, Kinnart, Inge, Wauters, Fieke, Terbeek, Joanne, Manders, Liselot, Wierda, Keimpe, Eggermont, Kristel, Madeiro, Rodrigo Furtado, Sue, Carolyn, Verfaillie, Catherine, Vandenberghe, Wim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762950/
https://www.ncbi.nlm.nih.gov/pubmed/36039535
http://dx.doi.org/10.1093/brain/awac313

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762950/
https://www.ncbi.nlm.nih.gov/pubmed/36039535
http://dx.doi.org/10.1093/brain/awac313

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