Cargando…

DJ-1 is an essential downstream mediator in PINK1/parkin-dependent mitophagy

Loss-of-function mutations in the PRKN, PINK1 and PARK7 genes (encoding parkin, PINK1 and DJ-1, respectively) cause autosomal recessive forms of Parkinson’s disease. PINK1 and parkin jointly mediate selective autophagy of damaged mitochondria (mitophagy), but the mechanisms by which loss of DJ-1 ind...

Descripción completa

Detalles Bibliográficos
Autores principales:	Imberechts, Dorien, Kinnart, Inge, Wauters, Fieke, Terbeek, Joanne, Manders, Liselot, Wierda, Keimpe, Eggermont, Kristel, Madeiro, Rodrigo Furtado, Sue, Carolyn, Verfaillie, Catherine, Vandenberghe, Wim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762950/ https://www.ncbi.nlm.nih.gov/pubmed/36039535 http://dx.doi.org/10.1093/brain/awac313

Ejemplares similares

Deficiency of parkin and PINK1 impairs age-dependent mitophagy in Drosophila
por: Cornelissen, Tom, et al.
Publicado: (2018)

Regulation of mitochondrial function by PINK1, Parkin and DJ-1
por: Giaime, Emilie, et al.
Publicado: (2013)

Hexokinases link DJ-1 to the PINK1/parkin pathway
por: Hauser, David N., et al.
Publicado: (2017)

Mitophagy and Parkinson's disease: The PINK1–parkin link()
por: Deas, Emma, et al.
Publicado: (2011)

Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection
por: Trempe, Jean-François, et al.
Publicado: (2013)

Loss of iron triggers PINK1/Parkin-independent mitophagy
por: Allen, George F G, et al.
Publicado: (2013)

Superoxide drives progression of Parkin/PINK1-dependent mitophagy following translocation of Parkin to mitochondria
por: Xiao, Bin, et al.
Publicado: (2017)

The three ‘P’s of mitophagy: PARKIN, PINK1, and post-translational modifications
por: Durcan, Thomas M., et al.
Publicado: (2015)

PINK1-parkin-mediated neuronal mitophagy deficiency in prion disease
por: Li, Jie, et al.
Publicado: (2022)

Inhibition of mitoNEET induces Pink1-Parkin-mediated mitophagy
por: Lee, Seunghee, et al.
Publicado: (2022)

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy
por: Matsuda, Noriyuki, et al.
Publicado: (2010)

Correction: Superoxide drives progression of Parkin/PINK1-dependent mitophagy following translocation of Parkin to mitochondria
por: Xiao, Bin, et al.
Publicado: (2018)

The contribution of Parkin, PINK1 and DJ‐1 genes to selective neuronal degeneration in Parkinson's disease
por: van der Vlag, Marc, et al.
Publicado: (2020)

PINK1 Is Dispensable for Mitochondrial Recruitment of Parkin and Activation of Mitophagy in Cardiac Myocytes
por: Kubli, Dieter A., et al.
Publicado: (2015)

Mitochondrial and lysosomal biogenesis are activated following PINK1/parkin‐mediated mitophagy
por: Ivankovic, Davor, et al.
Publicado: (2015)

Basal mitophagy is widespread in Drosophila but minimally affected by loss of Pink1 or parkin
por: Lee, Juliette J., et al.
Publicado: (2018)

Salidroside Protects Dopaminergic Neurons by Enhancing PINK1/Parkin-Mediated Mitophagy
por: Li, Ruru, et al.
Publicado: (2019)

PINK1/Parkin-mediated mitophagy in mechanical ventilation-induced diaphragmatic dysfunction
por: Yong, Hui, et al.
Publicado: (2021)

Cannabidiol activates PINK1-Parkin-dependent mitophagy and mitochondrial-derived vesicles
por: Ramirez, Adrian, et al.
Publicado: (2022)

Erythropoietin Mitigates Diabetic Nephropathy by Restoring PINK1/Parkin-Mediated Mitophagy
por: Yi, Xinyao, et al.
Publicado: (2022)

PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy
por: Shiba-Fukushima, Kahori, et al.
Publicado: (2012)

Parkin- and PINK1-Dependent Mitophagy in Neurons: Will the Real Pathway Please Stand Up?
por: Grenier, Karl, et al.
Publicado: (2013)

Morphological and bioenergetic demands underlying the mitophagy in post-mitotic neurons: the pink–parkin pathway
por: Amadoro, Giuseppina, et al.
Publicado: (2014)

Regulatory Roles of PINK1-Parkin and AMPK in Ubiquitin-Dependent Skeletal Muscle Mitophagy
por: Seabright, Alex P., et al.
Publicado: (2020)

The PINK1—Parkin mitophagy signalling pathway is not functional in peripheral blood mononuclear cells
por: Bradshaw, Aaron V., et al.
Publicado: (2021)

PINK1/Parkin‐mediated mitophagy enhances the survival of Staphylococcus aureus in bovine macrophages
por: Zhou, Xi, et al.
Publicado: (2023)

NDP52 acts as a redox sensor in PINK1/Parkin‐mediated mitophagy
por: Kataura, Tetsushi, et al.
Publicado: (2022)

A PINK1 input threshold arises from positive feedback in the PINK1/Parkin mitophagy decision circuit
por: Waters, Christopher S., et al.
Publicado: (2023)

Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin
por: Ashrafi, Ghazaleh, et al.
Publicado: (2014)

Counteracting PINK/Parkin Deficiency in the Activation of Mitophagy: A Potential Therapeutic Intervention for Parkinson’s Disease
por: Nardin, Alice, et al.
Publicado: (2016)

ATM mediates spermidine-induced mitophagy via PINK1 and Parkin regulation in human fibroblasts
por: Qi, Yongmei, et al.
Publicado: (2016)

Albumin Overload and PINK1/Parkin Signaling-Related Mitophagy in Renal Tubular Epithelial Cells
por: Tan, Jin, et al.
Publicado: (2018)

PINK1/Parkin-mediated mitophagy is activated in cisplatin nephrotoxicity to protect against kidney injury
por: Wang, Ying, et al.
Publicado: (2018)

RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway
por: Heo, J.-M., et al.
Publicado: (2018)

Berberine Promotes Cardiac Function by Upregulating PINK1/Parkin-Mediated Mitophagy in Heart Failure
por: Abudureyimu, Miyesaier, et al.
Publicado: (2020)

Vps13D functions in a Pink1-dependent and Parkin-independent mitophagy pathway
por: Shen, James L., et al.
Publicado: (2021)

Mitochondrial Ca(2+) oscillation induces mitophagy initiation through the PINK1-Parkin pathway
por: Yu, Zhengying, et al.
Publicado: (2021)

Exon Dosage Variations in Brazilian Patients with Parkinson’s Disease: Analysis of SNCA, PARKIN, PINK1 and DJ-1 Genes
por: Moura, Karla Cristina Vasconcelos, et al.
Publicado: (2012)

SWATH-MS proteome profiling data comparison of DJ-1, Parkin, and PINK1 knockout rat striatal mitochondria
por: Stauch, Kelly L., et al.
Publicado: (2016)

Nix restores mitophagy and mitochondrial function to protect against PINK1/Parkin-related Parkinson’s disease
por: Koentjoro, Brianada, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_2l08ne4l79gq4sril3oeq3krpr