An overview of PROTACs: a promising drug discovery paradigm

Proteolysis targeting chimeras (PROTACs) technology has emerged as a novel therapeutic paradigm in recent years. PROTACs are heterobifunctional molecules that degrade target proteins by hijacking the ubiquitin–proteasome system. Currently, about 20–25% of all protein targets are being studied, and m...

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Detalles Bibliográficos
Autores principales: Liu, Zi, Hu, Mingxing, Yang, Yu, Du, Chenghao, Zhou, Haoxuan, Liu, Chengyali, Chen, Yuanwei, Fan, Lei, Ma, Hongqun, Gong, Youling, Xie, Yongmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763089/
https://www.ncbi.nlm.nih.gov/pubmed/36536188
http://dx.doi.org/10.1186/s43556-022-00112-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763089/
https://www.ncbi.nlm.nih.gov/pubmed/36536188
http://dx.doi.org/10.1186/s43556-022-00112-0

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