AP1/Fra1 confers resistance to MAPK cascade inhibition in pancreatic cancer

Targeting KRAS downstream signaling remains an important therapeutic approach in pancreatic cancer. We used primary pancreatic ductal epithelial cells and mouse models allowing the conditional expression of oncogenic Kras(G12D), to investigate KRAS signaling integrators. We observed that the AP1 fam...

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Detalles Bibliográficos
Autores principales: Schneeweis, Christian, Diersch, Sandra, Hassan, Zonera, Krauß, Lukas, Schneider, Carolin, Lucarelli, Daniele, Falcomatà, Chiara, Steiger, Katja, Öllinger, Rupert, Krämer, Oliver H., Arlt, Alexander, Grade, Marian, Schmidt-Supprian, Marc, Hessmann, Elisabeth, Wirth, Matthias, Rad, Roland, Reichert, Maximilian, Saur, Dieter, Schneider, Günter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763154/
https://www.ncbi.nlm.nih.gov/pubmed/36534167
http://dx.doi.org/10.1007/s00018-022-04638-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763154/
https://www.ncbi.nlm.nih.gov/pubmed/36534167
http://dx.doi.org/10.1007/s00018-022-04638-y

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