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Footprints of a microbial toxin from the gut microbiome to mesencephalic mitochondria

OBJECTIVE: Idiopathic Parkinson’s disease (PD) is characterised by alpha-synuclein (aSyn) aggregation and death of dopaminergic neurons in the midbrain. Recent evidence posits that PD may initiate in the gut by microbes or their toxins that promote chronic gut inflammation that will ultimately impac...

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Detalles Bibliográficos
Autores principales: Esteves, A Raquel, Munoz-Pinto, Mário F, Nunes-Costa, Daniela, Candeias, Emanuel, Silva, Diana F, Magalhães, João D, Pereira-Santos, A Raquel, Ferreira, I Luisa, Alarico, Susana, Tiago, Igor, Empadinhas, Nuno, Cardoso, Sandra Morais
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763194/
https://www.ncbi.nlm.nih.gov/pubmed/34836918
http://dx.doi.org/10.1136/gutjnl-2021-326023