Cargando…

Single-cell RNA sequencing reveals intrahepatic and peripheral immune characteristics related to disease phases in HBV-infected patients

OBJECTIVE: A comprehensive immune landscape for HBV infection is pivotal to achieve HBV cure. DESIGN: We performed single-cell RNA sequencing of 2 43 000 cells from 46 paired liver and blood samples of 23 individuals, including six immune tolerant, 5 immune active (IA), 3 acute recovery (AR), 3 chro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Chao, Li, Jiesheng, Cheng, Yongqian, Meng, Fanping, Song, Jin-Wen, Fan, Xing, Fan, Hongtao, Li, Jing, Fu, Yu-Long, Zhou, Ming-Ju, Hu, Wei, Wang, Si-Yu, Fu, Yuan-Jie, Zhang, Ji-Yuan, Xu, Ruo-Nan, Shi, Ming, Hu, Xueda, Zhang, Zemin, Ren, Xianwen, Wang, Fu-Sheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2023
Materias:	Hepatology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763233/ https://www.ncbi.nlm.nih.gov/pubmed/35361683 http://dx.doi.org/10.1136/gutjnl-2021-325915

Ejemplares similares

Whole exome HBV DNA integration is independent of the intrahepatic HBV reservoir in HBeAg-negative chronic hepatitis B
por: Svicher, Valentina, et al.
Publicado: (2021)

Engineered anti-PDL1 with IFNα targets both immunoinhibitory and activating signals in the liver to break HBV immune tolerance
por: Meng, Chao-Yang, et al.
Publicado: (2023)

HBV infection-induced liver cirrhosis development in dual-humanised mice with human bone mesenchymal stem cell transplantation
por: Yuan, Lunzhi, et al.
Publicado: (2019)

PBMC transcriptomics identifies immune-metabolism disorder during the development of HBV-ACLF
por: Li, Jiang, et al.
Publicado: (2022)

The diagnostic and prognostic value of UBE2T in intrahepatic cholangiocarcinoma
por: Yu, Hua, et al.
Publicado: (2020)

Regulatory NK cells mediated between immunosuppressive monocytes and dysfunctional T cells in chronic HBV infection
por: Li, Haijun, et al.
Publicado: (2018)

Mass cytometry-based peripheral blood analysis as a novel tool for early detection of solid tumours: a multicentre study
por: Zhang, Qi, et al.
Publicado: (2023)

Fine needle aspirates comprehensively sample intrahepatic immunity
por: Gill, Upkar S, et al.
Publicado: (2019)

Racial disparities in transjugular intrahepatic portosystemic shunt procedure outcomes
por: Helzberg, James H, et al.
Publicado: (2022)

Less liver fibrosis marker increment in overweight chronic hepatitis B patients observed by age-adjusted Fibrosis-4 Index
por: Liu, Ta-Wei, et al.
Publicado: (2020)

Integration of tumour and viral genomic characterisations in HBV-related hepatocellular carcinomas
por: Amaddeo, Giuliana, et al.
Publicado: (2015)

Defining the key intrahepatic gene networks in HCV infection driven by sex
por: Marchi, Emanuele, et al.
Publicado: (2023)

Postoperative adjuvant transarterial chemoembolisation improves survival of hepatocellular carcinoma patients with microvascular invasion: A multicenter retrospective cohort
por: Luo, Laihui, et al.
Publicado: (2023)

Quantification of the hepatitis B virus cccDNA: evidence-based guidelines for monitoring the key obstacle of HBV cure
por: Allweiss, Lena, et al.
Publicado: (2023)

Placental growth factor promotes tumour desmoplasia and treatment resistance in intrahepatic cholangiocarcinoma
por: Aoki, Shuichi, et al.
Publicado: (2022)

Transjugular intrahepatic portosystemic shunt for the prevention of variceal rebleeding in cirrhotic patients with portal vein thrombosis: study protocol for a randomised controlled trial
por: Qi, Xingshun, et al.
Publicado: (2013)

TOX defines the degree of CD8+ T cell dysfunction in distinct phases of chronic HBV infection
por: Heim, Kathrin, et al.
Publicado: (2021)

Impact of HBsAg and HBcrAg levels on phenotype and function of HBV-specific T cells in patients with chronic hepatitis B virus infection
por: Aliabadi, Elmira, et al.
Publicado: (2022)

Therapeutic shutdown of HBV transcripts promotes reappearance of the SMC5/6 complex and silencing of the viral genome in vivo
por: Allweiss, Lena, et al.
Publicado: (2022)

First reports of clinical effects of transjugular intrahepatic portosystemic shunt in four patients with cirrhotic ascites refractory to tolvaptan
por: Tsuruya, Kota, et al.
Publicado: (2023)

Influence of surgical margin width on survival rate after resection of intrahepatic cholangiocarcinoma: a systematic review and meta-analysis
por: Jiang, Jing-Hua, et al.
Publicado: (2023)

Induction of IFN-λ3 as an additional effect of nucleotide, not nucleoside, analogues: a new potential target for HBV infection
por: Murata, Kazumoto, et al.
Publicado: (2018)

TG1050, an immunotherapeutic to treat chronic hepatitis B, induces robust T cells and exerts an antiviral effect in HBV-persistent mice
por: Martin, Perrine, et al.
Publicado: (2015)

Changing trends of hospitalisation of liver cirrhosis in Beijing, China
por: Bao, Xiao-Yuan, et al.
Publicado: (2015)

The gamma-glutamyl transpeptidase to platelet ratio (GPR) predicts significant liver fibrosis and cirrhosis in patients with chronic HBV infection in West Africa
por: Lemoine, Maud, et al.
Publicado: (2016)

Phenotypic CD8 T cell profiling in chronic hepatitis B to predict HBV-specific CD8 T cell susceptibility to functional restoration in vitro
por: Rossi, Marzia, et al.
Publicado: (2023)

Integrative metabolomic characterisation identifies altered portal vein serum metabolome contributing to human hepatocellular carcinoma
por: Liu, Jinkai, et al.
Publicado: (2022)

SIRT1-dependent mechanisms and effects of resveratrol for amelioration of muscle wasting in NASH mice
por: Liu, Chih-Wei, et al.
Publicado: (2020)

Cell-based cccDNA reporter assay combined with functional genomics identifies YBX1 as HBV cccDNA host factor and antiviral candidate target
por: Verrier, Eloi R, et al.
Publicado: (2023)

Gender differences in demographic and clinical characteristics in patients with HBV-related liver diseases in China
por: Liu, Mei, et al.
Publicado: (2022)

Dietary cholesterol drives fatty liver-associated liver cancer by modulating gut microbiota and metabolites
por: Zhang, Xiang, et al.
Publicado: (2021)

Randomised phase 2 study (JADE) of the HBV capsid assembly modulator JNJ-56136379 with or without a nucleos(t)ide analogue in patients with chronic hepatitis B infection
por: Janssen, Harry L A, et al.
Publicado: (2023)

Integrated multiomic analysis reveals comprehensive tumour heterogeneity and novel immunophenotypic classification in hepatocellular carcinomas
por: Zhang, Qi, et al.
Publicado: (2019)

Effect of splenectomy on the outcomes in patients with cirrhosis receiving transjugular intrahepatic portosystemic shunt
por: Yang, Chongtu, et al.
Publicado: (2021)

Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans
por: Che, Li, et al.
Publicado: (2020)

A new model predicts hepatocellular carcinoma in patients with HBV-related decompensated liver cirrhosis and long-term antiviral therapy: a prospective study
por: Mao, Hao-dan, et al.
Publicado: (2023)

Risk of hernia-related complications after transjugular intrahepatic portosystemic shunt creation in patients with pre-existing ventral abdominal hernias: 15-year experience at a quaternary medical center
por: McDaniel, Charles, et al.
Publicado: (2022)

Prevalence and clinical correlates of insomnia symptoms and their association with quality of life in Chinese patients with HBV-related liver disease
por: Zhao, Jing, et al.
Publicado: (2021)

From clinical variables to multiomics analysis: a margin morphology-based gross classification system for hepatocellular carcinoma stratification
por: Fan, Zhongqi, et al.
Publicado: (2023)

Using transjugular intrahepatic portosystemic shunt as the first‐line therapy in secondary prophylaxis of variceal hemorrhage
por: Liu, Jiacheng, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_a4cndeio3f5uq4d1qofav6ghid