Preclinical evaluation of the ROCK1 inhibitor, GSK269962A, in acute myeloid leukemia

Acute myeloid leukemia (AML) is an aggressive hematologic malignancy with high mortality that urgently requires new treatments. ROCK1 plays an essential role in regulating growth and survival in AML cells. In this study, we evaluated GSK269962A, a selective ROCK1 inhibitor, in preclinical models of...

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Detalles Bibliográficos
Autores principales: Pan, Ting, Wang, Sijia, Feng, Hao, Xu, Jiawen, Zhang, Miao, Yao, Yao, Xu, Kailin, Niu, Mingshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763303/
https://www.ncbi.nlm.nih.gov/pubmed/36561342
http://dx.doi.org/10.3389/fphar.2022.1064470

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763303/
https://www.ncbi.nlm.nih.gov/pubmed/36561342
http://dx.doi.org/10.3389/fphar.2022.1064470

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