Targeting the transcription factor HES1 by L-menthol restores protein phosphatase 6 in keratinocytes in models of psoriasis

Protein Phosphatase 6 down-regulation in keratinocytes is a pivotal event that amplifies the inflammatory circuits in psoriasis, indicating that restoration of protein phosphatase 6 can be a rational strategy for psoriasis treatment. Through the phenotypic screen, we here identify L-menthol that ame...

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Detalles Bibliográficos
Autores principales: Wang, Zhikai, Sun, Yang, Lou, Fangzhou, Bai, Jing, Zhou, Hong, Cai, Xiaojie, Sun, Libo, Yin, Qianqian, Tang, Sibei, Wu, Yue, Fan, Li, Xu, Zhenyao, Wang, Hong, Hu, Xiaoyu, Wang, Honglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763329/
https://www.ncbi.nlm.nih.gov/pubmed/36535970
http://dx.doi.org/10.1038/s41467-022-35565-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763329/
https://www.ncbi.nlm.nih.gov/pubmed/36535970
http://dx.doi.org/10.1038/s41467-022-35565-y

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