Rational enzyme design for enabling biocatalytic Baldwin cyclization and asymmetric synthesis of chiral heterocycles

Chiral heterocyclic compounds are needed for important medicinal applications. We report an in silico strategy for the biocatalytic synthesis of chiral N- and O-heterocycles via Baldwin cyclization modes of hydroxy- and amino-substituted epoxides and oxetanes using the limonene epoxide hydrolase fro...

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Detalles Bibliográficos
Autores principales: Li, Jun-Kuan, Qu, Ge, Li, Xu, Tian, Yuchen, Cui, Chengsen, Zhang, Fa-Guang, Zhang, Wuyuan, Ma, Jun-An, Reetz, Manfred T., Sun, Zhoutong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763437/
https://www.ncbi.nlm.nih.gov/pubmed/36535947
http://dx.doi.org/10.1038/s41467-022-35468-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763437/
https://www.ncbi.nlm.nih.gov/pubmed/36535947
http://dx.doi.org/10.1038/s41467-022-35468-y

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