Discovery of pyrrole derivatives as acetylcholinesterase-sparing butyrylcholinesterase inhibitor

Inspired by the crucial roles of (hetero)aryl rings in cholinesterase inhibitors and the pyrrole ring in new drug discovery, we synthesized 19 pyrrole derivatives and investigated their cholinesterase inhibitory activity. As a result, compounds 3o, 3p, and 3s with a 1,3-diaryl-pyrrole skeleton showe...

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Detalles Bibliográficos
Autores principales: Sun, Shouyuan, Shi, Tao, Peng, Yan, Zhang, Honghua, Zhuo, Linsheng, Peng, Xue, Li, Qien, Wang, Manxia, Wang, Shuzhi, Wang, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763612/
https://www.ncbi.nlm.nih.gov/pubmed/36561337
http://dx.doi.org/10.3389/fphar.2022.1043397

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763612/
https://www.ncbi.nlm.nih.gov/pubmed/36561337
http://dx.doi.org/10.3389/fphar.2022.1043397

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