Proteomic characterization of Toxoplasma gondii ME49 derived strains resistant to the artemisinin derivatives artemiside and artemisone implies potential mode of action independent of ROS formation

The sesquiterpene lactone artemisinin and its amino-artemisinin derivatives artemiside (GC008) and artemisone (GC003) are potent antimalarials. The mode of action of artemisinins against Plasmodium sp is popularly ascribed to 'activation' of the peroxide group by heme-Fe(II) or labile Fe(I...

Descripción completa

Detalles Bibliográficos
Autores principales: Müller, Joachim, Schlange, Carling, Heller, Manfred, Uldry, Anne-Christine, Braga-Lagache, Sophie, Haynes, Richard K., Hemphill, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Regular article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763631/
https://www.ncbi.nlm.nih.gov/pubmed/36512904
http://dx.doi.org/10.1016/j.ijpddr.2022.11.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763631/
https://www.ncbi.nlm.nih.gov/pubmed/36512904
http://dx.doi.org/10.1016/j.ijpddr.2022.11.005

Ejemplares similares