Mutations in the α4-α5 allosteric lobe of RAS do not significantly impair RAS signaling or self-association

Mutations in one of the three RAS genes (HRAS, KRAS, and NRAS) are present in nearly 20% of all human cancers. These mutations shift RAS to the GTP-loaded active state due to impairment in the intrinsic GTPase activity and disruption of GAP-mediated GTP hydrolysis, resulting in constitutive activati...

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Detalles Bibliográficos
Autores principales: Whaby, Michael, Wallon, Lauren, Mazzei, Megan, Khan, Imran, Teng, Kai Wen, Koide, Shohei, O’Bryan, John P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763690/
https://www.ncbi.nlm.nih.gov/pubmed/36334633
http://dx.doi.org/10.1016/j.jbc.2022.102661

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763690/
https://www.ncbi.nlm.nih.gov/pubmed/36334633
http://dx.doi.org/10.1016/j.jbc.2022.102661

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