Recent advances to combat ESKAPE pathogens with special reference to essential oils

Biofilm-associated bacteria, especially ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.), are a serious challenge worldwide. Due to the lack of discovery of novel antibiotics, in the past two...

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Autores principales: Panda, Sujogya Kumar, Buroni, Silvia, Swain, Shasank Sekhar, Bonacorsi, Andrea, da Fonseca Amorim, Erika Alves, Kulshrestha, Mukta, da Silva, Luis Cláudio Nascimento, Tiwari, Vishvanath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763703/
https://www.ncbi.nlm.nih.gov/pubmed/36560948
http://dx.doi.org/10.3389/fmicb.2022.1029098
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author Panda, Sujogya Kumar
Buroni, Silvia
Swain, Shasank Sekhar
Bonacorsi, Andrea
da Fonseca Amorim, Erika Alves
Kulshrestha, Mukta
da Silva, Luis Cláudio Nascimento
Tiwari, Vishvanath
author_facet Panda, Sujogya Kumar
Buroni, Silvia
Swain, Shasank Sekhar
Bonacorsi, Andrea
da Fonseca Amorim, Erika Alves
Kulshrestha, Mukta
da Silva, Luis Cláudio Nascimento
Tiwari, Vishvanath
author_sort Panda, Sujogya Kumar
collection PubMed
description Biofilm-associated bacteria, especially ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.), are a serious challenge worldwide. Due to the lack of discovery of novel antibiotics, in the past two decades, it has become necessary to search for new antibiotics or to study synergy with the existing antibiotics so as to counter life-threatening infections. Nature-derived compounds/based products are more efficient than the chemically synthesized ones with less resistance and lower side effects. In this descriptive review, we discuss the most promising therapeutics for the treatment of ESKAPE-related biofilms. The first aspect includes different types of natural agents [botanical drugs, essential oils (EOs), antimicrobial peptides, bacteriophages, and endolysins] effective against ESKAPE pathogens. The second part of the review deals with special references to EOs/essential oil components (EOCs) (with some exclusive examples), mode of action (via interfering in the quorum-sensing pathways, disruption of biofilm and their inhibitory concentrations, expression of genes that are involved, other virulence factors), existing in literature so far. Moreover, different essential oils and their major constituents were critically discussed using in vivo models to target ESKAPE pathogens along with the studies involving existing antibiotics.
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spelling pubmed-97637032022-12-21 Recent advances to combat ESKAPE pathogens with special reference to essential oils Panda, Sujogya Kumar Buroni, Silvia Swain, Shasank Sekhar Bonacorsi, Andrea da Fonseca Amorim, Erika Alves Kulshrestha, Mukta da Silva, Luis Cláudio Nascimento Tiwari, Vishvanath Front Microbiol Microbiology Biofilm-associated bacteria, especially ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.), are a serious challenge worldwide. Due to the lack of discovery of novel antibiotics, in the past two decades, it has become necessary to search for new antibiotics or to study synergy with the existing antibiotics so as to counter life-threatening infections. Nature-derived compounds/based products are more efficient than the chemically synthesized ones with less resistance and lower side effects. In this descriptive review, we discuss the most promising therapeutics for the treatment of ESKAPE-related biofilms. The first aspect includes different types of natural agents [botanical drugs, essential oils (EOs), antimicrobial peptides, bacteriophages, and endolysins] effective against ESKAPE pathogens. The second part of the review deals with special references to EOs/essential oil components (EOCs) (with some exclusive examples), mode of action (via interfering in the quorum-sensing pathways, disruption of biofilm and their inhibitory concentrations, expression of genes that are involved, other virulence factors), existing in literature so far. Moreover, different essential oils and their major constituents were critically discussed using in vivo models to target ESKAPE pathogens along with the studies involving existing antibiotics. Frontiers Media S.A. 2022-12-06 /pmc/articles/PMC9763703/ /pubmed/36560948 http://dx.doi.org/10.3389/fmicb.2022.1029098 Text en Copyright © 2022 Panda, Buroni, Swain, Bonacorsi, da Fonseca Amorim, Kulshrestha, da Silva and Tiwari. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Panda, Sujogya Kumar
Buroni, Silvia
Swain, Shasank Sekhar
Bonacorsi, Andrea
da Fonseca Amorim, Erika Alves
Kulshrestha, Mukta
da Silva, Luis Cláudio Nascimento
Tiwari, Vishvanath
Recent advances to combat ESKAPE pathogens with special reference to essential oils
title Recent advances to combat ESKAPE pathogens with special reference to essential oils
title_full Recent advances to combat ESKAPE pathogens with special reference to essential oils
title_fullStr Recent advances to combat ESKAPE pathogens with special reference to essential oils
title_full_unstemmed Recent advances to combat ESKAPE pathogens with special reference to essential oils
title_short Recent advances to combat ESKAPE pathogens with special reference to essential oils
title_sort recent advances to combat eskape pathogens with special reference to essential oils
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763703/
https://www.ncbi.nlm.nih.gov/pubmed/36560948
http://dx.doi.org/10.3389/fmicb.2022.1029098
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