Recent advances to combat ESKAPE pathogens with special reference to essential oils
Biofilm-associated bacteria, especially ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.), are a serious challenge worldwide. Due to the lack of discovery of novel antibiotics, in the past two...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763703/ https://www.ncbi.nlm.nih.gov/pubmed/36560948 http://dx.doi.org/10.3389/fmicb.2022.1029098 |
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author | Panda, Sujogya Kumar Buroni, Silvia Swain, Shasank Sekhar Bonacorsi, Andrea da Fonseca Amorim, Erika Alves Kulshrestha, Mukta da Silva, Luis Cláudio Nascimento Tiwari, Vishvanath |
author_facet | Panda, Sujogya Kumar Buroni, Silvia Swain, Shasank Sekhar Bonacorsi, Andrea da Fonseca Amorim, Erika Alves Kulshrestha, Mukta da Silva, Luis Cláudio Nascimento Tiwari, Vishvanath |
author_sort | Panda, Sujogya Kumar |
collection | PubMed |
description | Biofilm-associated bacteria, especially ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.), are a serious challenge worldwide. Due to the lack of discovery of novel antibiotics, in the past two decades, it has become necessary to search for new antibiotics or to study synergy with the existing antibiotics so as to counter life-threatening infections. Nature-derived compounds/based products are more efficient than the chemically synthesized ones with less resistance and lower side effects. In this descriptive review, we discuss the most promising therapeutics for the treatment of ESKAPE-related biofilms. The first aspect includes different types of natural agents [botanical drugs, essential oils (EOs), antimicrobial peptides, bacteriophages, and endolysins] effective against ESKAPE pathogens. The second part of the review deals with special references to EOs/essential oil components (EOCs) (with some exclusive examples), mode of action (via interfering in the quorum-sensing pathways, disruption of biofilm and their inhibitory concentrations, expression of genes that are involved, other virulence factors), existing in literature so far. Moreover, different essential oils and their major constituents were critically discussed using in vivo models to target ESKAPE pathogens along with the studies involving existing antibiotics. |
format | Online Article Text |
id | pubmed-9763703 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97637032022-12-21 Recent advances to combat ESKAPE pathogens with special reference to essential oils Panda, Sujogya Kumar Buroni, Silvia Swain, Shasank Sekhar Bonacorsi, Andrea da Fonseca Amorim, Erika Alves Kulshrestha, Mukta da Silva, Luis Cláudio Nascimento Tiwari, Vishvanath Front Microbiol Microbiology Biofilm-associated bacteria, especially ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.), are a serious challenge worldwide. Due to the lack of discovery of novel antibiotics, in the past two decades, it has become necessary to search for new antibiotics or to study synergy with the existing antibiotics so as to counter life-threatening infections. Nature-derived compounds/based products are more efficient than the chemically synthesized ones with less resistance and lower side effects. In this descriptive review, we discuss the most promising therapeutics for the treatment of ESKAPE-related biofilms. The first aspect includes different types of natural agents [botanical drugs, essential oils (EOs), antimicrobial peptides, bacteriophages, and endolysins] effective against ESKAPE pathogens. The second part of the review deals with special references to EOs/essential oil components (EOCs) (with some exclusive examples), mode of action (via interfering in the quorum-sensing pathways, disruption of biofilm and their inhibitory concentrations, expression of genes that are involved, other virulence factors), existing in literature so far. Moreover, different essential oils and their major constituents were critically discussed using in vivo models to target ESKAPE pathogens along with the studies involving existing antibiotics. Frontiers Media S.A. 2022-12-06 /pmc/articles/PMC9763703/ /pubmed/36560948 http://dx.doi.org/10.3389/fmicb.2022.1029098 Text en Copyright © 2022 Panda, Buroni, Swain, Bonacorsi, da Fonseca Amorim, Kulshrestha, da Silva and Tiwari. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Panda, Sujogya Kumar Buroni, Silvia Swain, Shasank Sekhar Bonacorsi, Andrea da Fonseca Amorim, Erika Alves Kulshrestha, Mukta da Silva, Luis Cláudio Nascimento Tiwari, Vishvanath Recent advances to combat ESKAPE pathogens with special reference to essential oils |
title | Recent advances to combat ESKAPE pathogens with special reference to essential oils |
title_full | Recent advances to combat ESKAPE pathogens with special reference to essential oils |
title_fullStr | Recent advances to combat ESKAPE pathogens with special reference to essential oils |
title_full_unstemmed | Recent advances to combat ESKAPE pathogens with special reference to essential oils |
title_short | Recent advances to combat ESKAPE pathogens with special reference to essential oils |
title_sort | recent advances to combat eskape pathogens with special reference to essential oils |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763703/ https://www.ncbi.nlm.nih.gov/pubmed/36560948 http://dx.doi.org/10.3389/fmicb.2022.1029098 |
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