Seeing spermine blocking of K(+) ion movement through inward rectifier Kir2.2 channels

Inwardly rectifier potassium (Kir) channels are a major potassium channel sub-class whose function is regulated by ligand-dependent gating and highly voltage-dependent block by polyamines. With molecular dynamics simulations over previously unattainable timescales, Jogini et al. (J. Gen. Physiol. ht...

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Detalles Bibliográficos
Autores principales: Lee, Sun-Joo, Nichols, Colin G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764022/
https://www.ncbi.nlm.nih.gov/pubmed/36524992
http://dx.doi.org/10.1085/jgp.202213144
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author Lee, Sun-Joo
Nichols, Colin G.
author_facet Lee, Sun-Joo
Nichols, Colin G.
author_sort Lee, Sun-Joo
collection PubMed
description Inwardly rectifier potassium (Kir) channels are a major potassium channel sub-class whose function is regulated by ligand-dependent gating and highly voltage-dependent block by polyamines. With molecular dynamics simulations over previously unattainable timescales, Jogini et al. (J. Gen. Physiol. https://doi.org/10.1085/jgp.202213085) provide unprecedented visualization of K(+) conduction through open Kir2.2 channels and of the molecular details of channel block by spermine.
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spelling pubmed-97640222023-06-16 Seeing spermine blocking of K(+) ion movement through inward rectifier Kir2.2 channels Lee, Sun-Joo Nichols, Colin G. J Gen Physiol Commentary Inwardly rectifier potassium (Kir) channels are a major potassium channel sub-class whose function is regulated by ligand-dependent gating and highly voltage-dependent block by polyamines. With molecular dynamics simulations over previously unattainable timescales, Jogini et al. (J. Gen. Physiol. https://doi.org/10.1085/jgp.202213085) provide unprecedented visualization of K(+) conduction through open Kir2.2 channels and of the molecular details of channel block by spermine. Rockefeller University Press 2022-12-16 /pmc/articles/PMC9764022/ /pubmed/36524992 http://dx.doi.org/10.1085/jgp.202213144 Text en © 2022 Lee and Nichols https://creativecommons.org/licenses/by-nc-sa/4.0/http://www.rupress.org/terms/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Lee, Sun-Joo
Nichols, Colin G.
Seeing spermine blocking of K(+) ion movement through inward rectifier Kir2.2 channels
title Seeing spermine blocking of K(+) ion movement through inward rectifier Kir2.2 channels
title_full Seeing spermine blocking of K(+) ion movement through inward rectifier Kir2.2 channels
title_fullStr Seeing spermine blocking of K(+) ion movement through inward rectifier Kir2.2 channels
title_full_unstemmed Seeing spermine blocking of K(+) ion movement through inward rectifier Kir2.2 channels
title_short Seeing spermine blocking of K(+) ion movement through inward rectifier Kir2.2 channels
title_sort seeing spermine blocking of k(+) ion movement through inward rectifier kir2.2 channels
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764022/
https://www.ncbi.nlm.nih.gov/pubmed/36524992
http://dx.doi.org/10.1085/jgp.202213144
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