The SCF–FBXW7 E3 ubiquitin ligase triggers degradation of histone 3 lysine 4 methyltransferase complex component WDR5 to prevent mitotic slippage

During prolonged mitotic arrest induced by antimicrotubule drugs, cell fate decision is determined by two alternative pathways, one leading to cell death and the other inducing premature escape from mitosis by mitotic slippage. FBWX7, a member of the F-box family of proteins and substrate-targeting...

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Detalles Bibliográficos
Autores principales: Hänle-Kreidler, Simon, Richter, Kai T., Hoffmann, Ingrid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764181/
https://www.ncbi.nlm.nih.gov/pubmed/36395886
http://dx.doi.org/10.1016/j.jbc.2022.102703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764181/
https://www.ncbi.nlm.nih.gov/pubmed/36395886
http://dx.doi.org/10.1016/j.jbc.2022.102703

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