Half-calcified calmodulin promotes basal activity and inactivation of the L-type calcium channel Ca(V)1.2

The L-type Ca(2+) channel Ca(V)1.2 controls gene expression, cardiac contraction, and neuronal activity. Calmodulin (CaM) governs Ca(V)1.2 open probability (Po) and Ca(2+)-dependent inactivation (CDI) but the mechanisms remain unclear. Here, we present electrophysiological data that identify a half...

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Detalles Bibliográficos
Autores principales: Bartels, Peter, Salveson, Ian, Coleman, Andrea M., Anderson, David E., Jeng, Grace, Estrada-Tobar, Zoila M., Man, Kwun Nok Mimi, Yu, Qinhong, Kuzmenkina, Elza, Nieves-Cintron, Madeline, Navedo, Manuel F., Horne, Mary C., Hell, Johannes W., Ames, James B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764201/
https://www.ncbi.nlm.nih.gov/pubmed/36395884
http://dx.doi.org/10.1016/j.jbc.2022.102701

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764201/
https://www.ncbi.nlm.nih.gov/pubmed/36395884
http://dx.doi.org/10.1016/j.jbc.2022.102701

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