Increased Percentage of CD8(+)CD28(−) Regulatory T Cells With Fingolimod Therapy in Multiple Sclerosis

BACKGROUND AND OBJECTIVES: Fingolimod, an oral therapy for MS, decreases expression of membrane S1P1 receptors on CD4(+) memory cells, causing their retention and deactivation in lymph nodes. We determined fingolimod effects on the number and proportion of potentially CNS-damaging CD8(+)CD28(+) cyto...

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Detalles Bibliográficos
Autores principales: Houston, Timothy W., Howlett-Prieto, Quentin, Regenauer, Colin, Testai, Fernando D., Yao, Faith, Feng, Xuan, Reder, Anthony T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764330/
https://www.ncbi.nlm.nih.gov/pubmed/36535763
http://dx.doi.org/10.1212/NXI.0000000000200075

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764330/
https://www.ncbi.nlm.nih.gov/pubmed/36535763
http://dx.doi.org/10.1212/NXI.0000000000200075

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