PTEN and LKB1 are differentially required in Gli1-expressing mesenchymal cells to suppress gastrointestinal polyposis

PTEN and LKB1 are intimately associated with gastrointestinal tumorigenesis. Mutations of PTEN or LKB1 lead to Cowden syndrome and Peutz-Jeghers syndrome characterized by development of gastrointestinal polyps. However, the cells of origin of these polyps and underlying mechanism remain unclear. Her...

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Detalles Bibliográficos
Autores principales: Cotton, Jennifer L., Dang, Kyvan, Hu, Lu, Sun, Yang, Singh, Alka, Rajurkar, Mihir S., Li, Qi, Wu, Xu, Mao, Junhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764383/
https://www.ncbi.nlm.nih.gov/pubmed/35858546
http://dx.doi.org/10.1016/j.celrep.2022.111125

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764383/
https://www.ncbi.nlm.nih.gov/pubmed/35858546
http://dx.doi.org/10.1016/j.celrep.2022.111125

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