Logistic Regression-Guided Identification of Cofactor Specificity-Contributing Residues in Enzyme with Sequence Datasets Partitioned by Catalytic Properties

[Image: see text] Changing the substrate/cofactor specificity of an enzyme requires multiple mutations at spatially adjacent positions around the substrate pocket. However, this is challenging when solely based on crystal structure information because enzymes undergo dynamic conformational changes d...

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Detalles Bibliográficos
Autores principales: Sugiki, Sou, Niide, Teppei, Toya, Yoshihiro, Shimizu, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764414/
https://www.ncbi.nlm.nih.gov/pubmed/36321539
http://dx.doi.org/10.1021/acssynbio.2c00315

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764414/
https://www.ncbi.nlm.nih.gov/pubmed/36321539
http://dx.doi.org/10.1021/acssynbio.2c00315

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