Developmental phenomics suggests that H3K4 monomethylation confers multi-level phenotypic robustness

How histone modifications affect animal development remains difficult to ascertain. Despite the prevalence of histone 3 lysine 4 monomethylation (H3K4me1) on enhancers, hypomethylation appears to have minor effects on phenotype and viability. Here, we genetically reduce H3K4me1 deposition in Drosoph...

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Detalles Bibliográficos
Autores principales: Gandara, Lautaro, Tsai, Albert, Ekelöf, Måns, Galupa, Rafael, Preger-Ben Noon, Ella, Alexandrov, Theodore, Crocker, Justin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764455/
https://www.ncbi.nlm.nih.gov/pubmed/36516782
http://dx.doi.org/10.1016/j.celrep.2022.111832

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764455/
https://www.ncbi.nlm.nih.gov/pubmed/36516782
http://dx.doi.org/10.1016/j.celrep.2022.111832

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