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Signaling pathways, microenvironment, and targeted treatments in Langerhans cell histiocytosis
Langerhans cell histiocytosis (LCH) is an inflammatory myeloid malignancy in the “L-group” histiocytosis. Mitogen-activated protein kinase (MAPK) pathway activating mutations are detectable in nearly all LCH lesions. However, the pathogenic roles of MAPK pathway activation in the development of hist...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764551/ https://www.ncbi.nlm.nih.gov/pubmed/36536400 http://dx.doi.org/10.1186/s12964-022-00917-0 |