Identification of antibodies cross-reactive with woodchuck immune cells and activation of virus-specific and global cytotoxic T cell responses by anti-PD-1 and anti-PD-L1 in experimental chronic hepatitis B and persistent occult hepadnaviral infection

Woodchuck (Marmota monax) infected with woodchuck hepatitis virus (WHV) is the most pathogenically compatible naturally occurring model of human hepatitis B virus (HBV) infection, chronic hepatitis B, and HBV-induced hepatocellular carcinoma. This system plays a crucial role in discovery and preclin...

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Detalles Bibliográficos
Autores principales: Corkum, Christopher P., Wiede, Louisa L., Ruble, Cara L.-A., Qiu, Jiabin, Mulrooney-Cousins, Patricia M., Steeves, Meredith A., Watson, David E., Michalak, Tomasz I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764628/
https://www.ncbi.nlm.nih.gov/pubmed/36560951
http://dx.doi.org/10.3389/fmicb.2022.1011070

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764628/
https://www.ncbi.nlm.nih.gov/pubmed/36560951
http://dx.doi.org/10.3389/fmicb.2022.1011070

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