Decreased SUV39H1 at the promoter region leads to increased CREMα and accelerates autoimmune response in CD4(+) T cells from patients with systemic lupus erythematosus

BACKGROUND: Overproduction of cAMP-responsive element modulator α (CREMα) in total T cells from patients with systemic lupus erythematosus (SLE) can inhibit IL-2 and increase IL-17A. These ultimately promote progression of SLE. This study aims to investigate the expression of CREMα in SLE CD4(+) T c...

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Detalles Bibliográficos
Autores principales: Luo, Shuangyan, Zhang, Huilin, Xie, Yuming, Huang, Junke, Luo, Danhong, Zhang, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764740/
https://www.ncbi.nlm.nih.gov/pubmed/36536372
http://dx.doi.org/10.1186/s13148-022-01411-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764740/
https://www.ncbi.nlm.nih.gov/pubmed/36536372
http://dx.doi.org/10.1186/s13148-022-01411-7

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