Neuropilin-1 Mediates SARS-CoV-2 Infection of Astrocytes in Brain Organoids, Inducing Inflammation Leading to Dysfunction and Death of Neurons

Coronavirus disease 2019 (COVID-19) is frequently associated with neurological deficits, but how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces these effects remains unclear. Here, we show that astrocytes are readily infected by SARS-CoV-2, but surprisingly, neuropilin-1, not a...

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Detalles Bibliográficos
Autores principales: Kong, Weili, Montano, Mauricio, Corley, Michael J., Helmy, Ekram, Kobayashi, Hirofumi, Kinisu, Martin, Suryawanshi, Rahul, Luo, Xiaoyu, Royer, Loic A., Roan, Nadia R., Ott, Melanie, Ndhlovu, Lishomwa C., Greene, Warner C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9765283/
https://www.ncbi.nlm.nih.gov/pubmed/36314791
http://dx.doi.org/10.1128/mbio.02308-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9765283/
https://www.ncbi.nlm.nih.gov/pubmed/36314791
http://dx.doi.org/10.1128/mbio.02308-22

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