Efficacy of APX2039 in a Rabbit Model of Cryptococcal Meningitis

Cryptococcal Meningitis (CM) is uniformly fatal if not treated, and treatment options are limited. We previously reported on the activity of APX2096, the prodrug of the novel Gwt1 inhibitor APX2039, in a mouse model of CM. Here, we investigated the efficacy of APX2039 in mouse and rabbit models of C...

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Detalles Bibliográficos
Autores principales: Giamberardino, Charles D., Schell, Wiley A., Tenor, Jennifer L., Toffaletti, Dena L., Palmucci, Julia R., Marius, Choiselle, Boua, Jane-Valeriane K., Soltow, Quinlyn, Mansbach, Robert, Moseley, M. Arthur, Thompson, J. Will, Dubois, Laura G., Hope, William, Perfect, John R., Shaw, Karen Joy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9765414/
https://www.ncbi.nlm.nih.gov/pubmed/36222509
http://dx.doi.org/10.1128/mbio.02347-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9765414/
https://www.ncbi.nlm.nih.gov/pubmed/36222509
http://dx.doi.org/10.1128/mbio.02347-22

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