Antibiotic Acyldepsipeptides Stimulate the Streptomyces Clp-ATPase/ClpP Complex for Accelerated Proteolysis

Clp proteases consist of a proteolytic, tetradecameric ClpP core and AAA+ Clp-ATPases. Streptomycetes, producers of a plethora of secondary metabolites, encode up to five different ClpP homologs, and the composition of their unusually complex Clp protease machinery has remained unsolved. Here, we re...

Descripción completa

Detalles Bibliográficos
Autores principales: Reinhardt, Laura, Thomy, Dhana, Lakemeyer, Markus, Westermann, Linda Maria, Ortega, Joaquin, Sieber, Stephan A., Sass, Peter, Brötz-Oesterhelt, Heike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9765437/
https://www.ncbi.nlm.nih.gov/pubmed/36286522
http://dx.doi.org/10.1128/mbio.01413-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9765437/
https://www.ncbi.nlm.nih.gov/pubmed/36286522
http://dx.doi.org/10.1128/mbio.01413-22

Ejemplares similares