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Antibiotic Acyldepsipeptides Stimulate the Streptomyces Clp-ATPase/ClpP Complex for Accelerated Proteolysis

Clp proteases consist of a proteolytic, tetradecameric ClpP core and AAA+ Clp-ATPases. Streptomycetes, producers of a plethora of secondary metabolites, encode up to five different ClpP homologs, and the composition of their unusually complex Clp protease machinery has remained unsolved. Here, we re...

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Detalles Bibliográficos
Autores principales:	Reinhardt, Laura, Thomy, Dhana, Lakemeyer, Markus, Westermann, Linda Maria, Ortega, Joaquin, Sieber, Stephan A., Sass, Peter, Brötz-Oesterhelt, Heike
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9765437/ https://www.ncbi.nlm.nih.gov/pubmed/36286522 http://dx.doi.org/10.1128/mbio.01413-22

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