Metabolic Promiscuity of an Orphan Small Alarmone Hydrolase Facilitates Bacterial Environmental Adaptation

Small alarmone hydrolases (SAHs) are alarmone metabolizing enzymes found in both metazoans and bacteria. In metazoans, the SAH homolog Mesh1 is reported to function in cofactor metabolism by hydrolyzing NADPH to NADH. In bacteria, SAHs are often identified in genomes with toxic alarmone synthetases...

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Detalles Bibliográficos
Autores principales: Fung, Danny K., Bai, Kaihong, Yang, Jin, Xu, Xiaoli, Stevenson, David M., Amador-Noguez, Daniel, Luo, Laixin, Wang, Jue D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9765508/
https://www.ncbi.nlm.nih.gov/pubmed/36472432
http://dx.doi.org/10.1128/mbio.02422-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9765508/
https://www.ncbi.nlm.nih.gov/pubmed/36472432
http://dx.doi.org/10.1128/mbio.02422-22

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