Cargando…

Structural Foundations of Potassium Selectivity in Channelrhodopsins

Potassium-selective channelrhodopsins (KCRs) are light-gated K(+) channels recently found in the stramenopile protist Hyphochytrium catenoides. When expressed in neurons, KCRs enable high-precision optical inhibition of spiking (optogenetic silencing). KCRs are capable of discriminating K(+) from Na...

Descripción completa

Detalles Bibliográficos
Autores principales:	Govorunova, Elena G., Sineshchekov, Oleg A., Brown, Leonid S., Bondar, Ana-Nicoleta, Spudich, John L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9765531/ https://www.ncbi.nlm.nih.gov/pubmed/36413022 http://dx.doi.org/10.1128/mbio.03039-22

Ejemplares similares

Emerging Diversity of Channelrhodopsins and Their Structure-Function Relationships
por: Govorunova, Elena G., et al.
Publicado: (2022)

Structures of channelrhodopsin paralogs in peptidiscs explain their contrasting K(+) and Na(+) selectivities
por: Morizumi, Takefumi, et al.
Publicado: (2023)

Anion channelrhodopsins for inhibitory cardiac optogenetics
por: Govorunova, Elena G., et al.
Publicado: (2016)

New Channelrhodopsin with a Red-Shifted Spectrum and Rapid Kinetics from Mesostigma viride
por: Govorunova, Elena G., et al.
Publicado: (2011)

Conductance Mechanisms of Rapidly Desensitizing Cation Channelrhodopsins from Cryptophyte Algae
por: Sineshchekov, Oleg A., et al.
Publicado: (2020)

Crystal structure of a natural light-gated anion channelrhodopsin
por: Li, Hai, et al.
Publicado: (2019)

Cation and Anion Channelrhodopsins: Sequence Motifs and Taxonomic Distribution
por: Govorunova, Elena G., et al.
Publicado: (2021)

Extending the Time Domain of Neuronal Silencing with Cryptophyte Anion Channelrhodopsins
por: Govorunova, Elena G., et al.
Publicado: (2018)

The Expanding Family of Natural Anion Channelrhodopsins Reveals Large Variations in Kinetics, Conductance, and Spectral Sensitivity
por: Govorunova, Elena G., et al.
Publicado: (2017)

Biophysical characterization of light-gated ion channels using planar automated patch clamp
por: Govorunova, Elena G., et al.
Publicado: (2022)

Structural basis for ion selectivity in potassium-selective channelrhodopsins
por: Tajima, Seiya, et al.
Publicado: (2023)

Sequential absorption of two photons creates a bistable form of RubyACR responsible for its strong desensitization
por: Sineshchekov, Oleg A., et al.
Publicado: (2023)

The crystal structure of bromide-bound GtACR1 reveals a pre-activated state in the transmembrane anion tunnel
por: Li, Hai, et al.
Publicado: (2021)

Mechanism by which water and protein electrostatic interactions control proton transfer at the active site of channelrhodopsin
por: Adam, Suliman, et al.
Publicado: (2018)

Retinal Chromophore Structure and Schiff Base Interactions in Red-Shifted Channelrhodopsin-1 from Chlamydomonas augustae
por: Ogren, John I., et al.
Publicado: (2014)

Comparison of the Structural Changes Occurring during the Primary Phototransition of Two Different Channelrhodopsins from Chlamydomonas Algae
por: Ogren, John I., et al.
Publicado: (2014)

Attractant and Repellent Signaling Conformers of Sensory Rhodopsin−Transducer Complexes
por: Sineshchekov, Oleg A., et al.
Publicado: (2010)

Transient, Consequential Increases in Extracellular Potassium Ions Accompany Channelrhodopsin2 Excitation
por: Octeau, J. Christopher, et al.
Publicado: (2019)

WiChR, a highly potassium-selective channelrhodopsin for low-light one- and two-photon inhibition of excitable cells
por: Vierock, Johannes, et al.
Publicado: (2022)

From channelrhodopsins to optogenetics
por: Hegemann, Peter, et al.
Publicado: (2013)

His166 Is the Schiff Base Proton Acceptor in Attractant Phototaxis Receptor Sensory Rhodopsin I
por: Sasaki, Jun, et al.
Publicado: (2014)

Crystal structure of the red light-activated channelrhodopsin Chrimson
por: Oda, Kazumasa, et al.
Publicado: (2018)

Cryo-EM structures of the channelrhodopsin ChRmine in lipid nanodiscs
por: Tucker, Kyle, et al.
Publicado: (2022)

In Channelrhodopsin-2 Glu-90 Is Crucial for Ion Selectivity and Is Deprotonated during the Photocycle
por: Eisenhauer, Kirstin, et al.
Publicado: (2012)

Molecular determinants of proton selectivity and gating in the red-light activated channelrhodopsin Chrimson
por: Vierock, Johannes, et al.
Publicado: (2017)

Crystal structure of the natural anion-conducting channelrhodopsin GtACR1
por: Kim, Yoon Seok, et al.
Publicado: (2018)

Calcium-permeable channelrhodopsins for the photocontrol of calcium signalling
por: Fernandez Lahore, Rodrigo G., et al.
Publicado: (2022)

Channelrhodopsin-2 Localised to the Axon Initial Segment
por: Grubb, Matthew S., et al.
Publicado: (2010)

Activity-dependent expression of Channelrhodopsin at neuronal synapses
por: Gobbo, Francesco, et al.
Publicado: (2017)

Proton transfer pathway in anion channelrhodopsin-1
por: Tsujimura, Masaki, et al.
Publicado: (2021)

Time-resolved serial femtosecond crystallography reveals early structural changes in channelrhodopsin
por: Oda, Kazumasa, et al.
Publicado: (2021)

Strategies for Expanding the Operational Range of Channelrhodopsin in Optogenetic Vision
por: Mutter, Marion, et al.
Publicado: (2013)

The Effects of Repetitive Use and Pathological Remodeling on Channelrhodopsin Function in Cardiomyocytes
por: Ördög, Balázs, et al.
Publicado: (2021)

Reaction dynamics of the chimeric channelrhodopsin C1C2
por: Hontani, Yusaku, et al.
Publicado: (2017)

Cortical Neurovascular Coupling Driven by Stimulation of Channelrhodopsin-2
por: Ji, Lijun, et al.
Publicado: (2012)

Delivery of continuously-varying stimuli using channelrhodopsin-2
por: Tchumatchenko, Tatjana, et al.
Publicado: (2013)

Time-resolved infrared spectroscopic techniques as applied to channelrhodopsin
por: Ritter, Eglof, et al.
Publicado: (2015)

Femtosecond infrared spectroscopy of channelrhodopsin-1 chromophore isomerization
por: Stensitzki, T., et al.
Publicado: (2016)

Molecular Dynamics of Channelrhodopsin at the Early Stages of Channel Opening
por: Takemoto, Mizuki, et al.
Publicado: (2015)

Optical inhibition of larval zebrafish behaviour with anion channelrhodopsins
por: Mohamed, Gadisti Aisha, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_1ddf7l335fm1bp4hkka6emf96n