Cargando…

A Persistent Tuberculosis Outbreak in the UK Is Characterized by Hydrophobic fadB4-Deficient Mycobacterium tuberculosis That Replicates Rapidly in Macrophages

The genetic diversity of Mycobacterium tuberculosis can influence disease severity and transmissibility. To better understand how this diversity influences individuals and communities, we phenotyped M. tuberculosis that was causing a persistent outbreak in the East Midlands, United Kingdom. Compared...

Descripción completa

Detalles Bibliográficos
Autores principales:	Farzand, Robeena, Haigh, Richard D., Monk, Philip, Haldar, Pranabashis, Patel, Hemu, Pareek, Manish, Verma, Raman, Barer, Michael R., Woltmann, Gerrit, Ahyow, Lauren, Jagatia, Heena, Decker, Jonathan, Mukamolova, Galina V., Cooper, Andrea M., Garton, Natalie J., O’Hare, Helen M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9765663/ https://www.ncbi.nlm.nih.gov/pubmed/36374090 http://dx.doi.org/10.1128/mbio.02656-22

Ejemplares similares

Crystal structure of Mycobacterium tuberculosis FadB2 implicated in mycobacterial β-oxidation
por: Cox, Jonathan A. G., et al.
Publicado: (2019)

Face Mask Sampling for the Detection of Mycobacterium tuberculosis in Expelled Aerosols
por: Williams, Caroline M. L., et al.
Publicado: (2014)

A Virulence Associated Siderophore Importer Reduces Antimicrobial Susceptibility of Klebsiella pneumoniae
por: Farzand, Robeena, et al.
Publicado: (2021)

The Mycobacterium tuberculosis β-oxidation genes echA5 and fadB3 are dispensable for growth in vitro and in vivo
por: Williams, Kerstin J., et al.
Publicado: (2011)

ICEKp2: description of an integrative and conjugative element in Klebsiella pneumoniae, co-occurring and interacting with ICEKp1
por: Farzand, Robeena, et al.
Publicado: (2019)

Phenotypically Adapted Mycobacterium tuberculosis Populations from Sputum Are Tolerant to First-Line Drugs
por: Turapov, Obolbek, et al.
Publicado: (2016)

Staphylococcus aureus FadB is a dehydrogenase that mediates cholate resistance and survival under human colonic conditions
por: Alsultan, Amjed, et al.
Publicado: (2023)

Exhaled Mycobacterium tuberculosis output and detection of subclinical disease by face-mask sampling: prospective observational studies
por: Williams, Caroline M, et al.
Publicado: (2020)

The Role of Complement System and the Immune Response to Tuberculosis Infection
por: Jagatia, Heena, et al.
Publicado: (2021)

Exhaled Mycobacterium tuberculosis Predicts Incident Infection in Household Contacts
por: Williams, Caroline M, et al.
Publicado: (2022)

A nested case–control study of predictors for tuberculosis recurrence in a large UK Centre
por: Rosser, Andrew, et al.
Publicado: (2018)

Protein kinase B controls Mycobacterium tuberculosis growth via phosphorylation of the transcriptional regulator Lsr2 at threonine 112
por: Alqaseer, Kawther, et al.
Publicado: (2019)

(S)-3-hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase (FadB’) from fatty acid degradation operon of Ralstonia eutropha H16
por: Volodina, Elena, et al.
Publicado: (2014)

The role of hydrophobicity in tuberculosis evolution and pathogenicity
por: Jankute, Monika, et al.
Publicado: (2017)

Blood transcriptomics reveal the evolution and resolution of the immune response in tuberculosis
por: Tabone, Olivier, et al.
Publicado: (2021)

Coupling of Peptidoglycan Synthesis to Central Metabolism in Mycobacteria: Post-transcriptional Control of CwlM by Aconitase
por: Bancroft, Peter J., et al.
Publicado: (2020)

Difference in persistent tuberculosis bacteria between in vitro and sputum from patients: implications for translational predictions
por: Faraj, Alan, et al.
Publicado: (2020)

A modular transcriptional signature identifies phenotypic heterogeneity of human tuberculosis infection
por: Singhania, Akul, et al.
Publicado: (2018)

12 Exhaled SARS-CoV-2 viral load kinetics measured by facemask sampling and its association with household transmission – a longitudinal cohort study
por: Pan, Daniel, et al.
Publicado: (2022)

Vulnerability and tuberculosis treatment outcomes in urban settings in England: A mixed-methods study
por: Berrocal-Almanza, Luis C., et al.
Publicado: (2023)

Exhaled SARS-CoV-2 RNA viral load kinetics measured by facemask sampling associates with household transmission
por: Pan, Daniel, et al.
Publicado: (2023)

A data-driven framework for clinical decision support applied to pneumonia management
por: Free, Robert C., et al.
Publicado: (2023)

Development of a robust and quantitative high-throughput screening method for assessing phenotypic variation in large Neisseria meningitidis isolate collections
por: Farzand, Robeena, et al.
Publicado: (2023)

Specialist pneumonia intervention nurse service improves pneumonia care and outcome
por: Free, Robert C, et al.
Publicado: (2021)

Dimethyl fumarate eliminates differentially culturable Mycobacterium tuberculosis in an intranasal murine model of tuberculosis
por: Glenn, Sarah M., et al.
Publicado: (2022)

Patient profiles and clinical utility of mepolizumab in severe eosinophilic asthma
por: Haldar, Pranabashis
Publicado: (2017)

Demographic and Clinical Determinants of Tuberculosis and TB Recurrence: A Double-Edged Retrospective Study from Pakistan
por: Mujtaba, Mariam Ahmed, et al.
Publicado: (2022)

The impact, effectiveness and outcomes of targeted screening thresholds for programmatic latent tuberculosis infection testing in HIV
por: White, Helena A., et al.
Publicado: (2022)

Latent tuberculosis screening and treatment in HIV: highly acceptable in a prospective cohort study
por: White, Helena A., et al.
Publicado: (2022)

Cannabis use and the risk of tuberculosis: a systematic review
por: French, Clare E., et al.
Publicado: (2019)

Microarrays for Public Health: Genomic Epidemiology of Tuberculosis
por: Shafi, Jamila, et al.
Publicado: (2002)

Tuberculosis in UK cities: workload and effectiveness of tuberculosis control programmes
por: Bothamley, Graham H, et al.
Publicado: (2011)

Screening of immigrants in the UK for imported latent tuberculosis: a multicentre cohort study and cost-effectiveness analysis
por: Pareek, Manish, et al.
Publicado: (2011)

Association Between Pathogens Detected Using Quantitative Polymerase Chain Reaction With Airway Inflammation in COPD at Stable State and Exacerbations
por: Barker, Bethan L., et al.
Publicado: (2015)

The Key Roles of Mycobacterium tuberculosis FadD23 C-terminal Domain in Catalytic Mechanisms
por: Yan, Mengrong, et al.
Publicado: (2023)

Airway bacteria measured by quantitative polymerase chain reaction and culture in patients with stable COPD: relationship with neutrophilic airway inflammation, exacerbation frequency, and lung function
por: Bafadhel, Mona, et al.
Publicado: (2015)

Crystal Structure of Fad35R from Mycobacterium tuberculosis H37Rv in the Apo-State
por: Singh, Appu Kumar, et al.
Publicado: (2015)

Estimating epidemiological parameters for bovine tuberculosis in British cattle using a Bayesian partial-likelihood approach
por: O'Hare, A., et al.
Publicado: (2014)

Exhaled SARS-CoV-2 quantified by face-mask sampling in hospitalised patients with COVID-19
por: Williams, Caroline M., et al.
Publicado: (2021)

Designing novel inhibitors against Mycobacterium tuberculosis FadA5 (acetyl-CoA acetyltransferase) by virtual screening of known anti-tuberculosis (bioactive) compounds
por: Jaiswal, Atul Kumar, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_klj9ld88nid687qj8di07ijroo