Rotavirus NSP1 Subverts the Antiviral Oligoadenylate Synthetase-RNase L Pathway by Inducing RNase L Degradation

The interferon (IFN)-inducible 2′,5′-oligoadenylate synthetase (OAS)-RNase L pathway plays a critical role in antiviral immunity. Group A rotaviruses, including the simian SA11 strain, inhibit this pathway through two activities: an E3-ligase related activity of NSP1 that degrades proteins necessary...

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Detalles Bibliográficos
Autores principales: Dai, Jin, Yi, Guanghui, Philip, Asha A., Patton, John T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9765674/
https://www.ncbi.nlm.nih.gov/pubmed/36413023
http://dx.doi.org/10.1128/mbio.02995-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9765674/
https://www.ncbi.nlm.nih.gov/pubmed/36413023
http://dx.doi.org/10.1128/mbio.02995-22

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