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LEVERAGING THE NDUFS4-/- MOUSE AS A PLATFORM FOR TESTING LONGEVITY INTERVENTIONS
Mitochondrial dysfunction is one of the hallmarks of biological aging, as well as the driving factor for mitochondrial diseases. Up to 30% of mitochondrial disorders are due to mutations affecting the activity of Complex I in the electron transport chain. Loss of the Complex I subunit Ndufs4 recapit...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9767139/ http://dx.doi.org/10.1093/geroni/igac059.2663 |