RAD18 opposes transcription-associated genome instability through FANCD2 recruitment

DNA replication is a vulnerable time for genome stability maintenance. Intrinsic stressors, as well as oncogenic stress, can challenge replication by fostering conflicts with transcription and stabilizing DNA:RNA hybrids. RAD18 is an E3 ubiquitin ligase for PCNA that is involved in coordinating DNA...

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Detalles Bibliográficos
Autores principales: Wells, James P., Chang, Emily Yun-Chia, Dinatto, Leticia, White, Justin, Ryall, Stephanie, Stirling, Peter C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9767342/
https://www.ncbi.nlm.nih.gov/pubmed/36480547
http://dx.doi.org/10.1371/journal.pgen.1010309

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9767342/
https://www.ncbi.nlm.nih.gov/pubmed/36480547
http://dx.doi.org/10.1371/journal.pgen.1010309

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