Discovery of small molecule mechanistic target of rapamycin inhibitors as anti-aging and anti-cancer therapeutics

To date, the most studied drug in anti-aging research is the mTOR inhibitor – rapamycin. Despite its almost perfect anti-aging profile, rapamycin exerts one significant limitation – inappropriate physicochemical properties. Therefore, we have decided to utilize virtual high-throughput screening and...

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Detalles Bibliográficos
Autores principales: Chrienova, Zofia, Rysanek, David, Oleksak, Patrik, Stary, Dorota, Bajda, Marek, Reinis, Milan, Mikyskova, Romana, Novotny, Ondrej, Andrys, Rudolf, Skarka, Adam, Vasicova, Pavla, Novak, Josef, Valis, Martin, Kuca, Kamil, Hodny, Zdenek, Nepovimova, Eugenie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Aging Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9767416/
https://www.ncbi.nlm.nih.gov/pubmed/36561137
http://dx.doi.org/10.3389/fnagi.2022.1048260

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9767416/
https://www.ncbi.nlm.nih.gov/pubmed/36561137
http://dx.doi.org/10.3389/fnagi.2022.1048260

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