Cargando…

Discovery of small molecule mechanistic target of rapamycin inhibitors as anti-aging and anti-cancer therapeutics

To date, the most studied drug in anti-aging research is the mTOR inhibitor – rapamycin. Despite its almost perfect anti-aging profile, rapamycin exerts one significant limitation – inappropriate physicochemical properties. Therefore, we have decided to utilize virtual high-throughput screening and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chrienova, Zofia, Rysanek, David, Oleksak, Patrik, Stary, Dorota, Bajda, Marek, Reinis, Milan, Mikyskova, Romana, Novotny, Ondrej, Andrys, Rudolf, Skarka, Adam, Vasicova, Pavla, Novak, Josef, Valis, Martin, Kuca, Kamil, Hodny, Zdenek, Nepovimova, Eugenie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Aging Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9767416/ https://www.ncbi.nlm.nih.gov/pubmed/36561137 http://dx.doi.org/10.3389/fnagi.2022.1048260

Ejemplares similares

Rapamycin: Drug Repurposing in SARS-CoV-2 Infection
por: Patocka, Jiri, et al.
Publicado: (2021)

Privileged multi-target directed propargyl-tacrines combining cholinesterase and monoamine oxidase inhibition activities
por: Chrienova, Zofia, et al.
Publicado: (2022)

The role of mTOR in age-related diseases
por: Chrienova, Zofia, et al.
Publicado: (2021)

STAT3 inhibitor Stattic and its analogues inhibit STAT3 phosphorylation and modulate cytokine secretion in senescent tumour cells
por: Mikyskova, Romana, et al.
Publicado: (2023)

Neuropharmacology of Cevimeline and Muscarinic Drugs—Focus on Cognition and Neurodegeneration
por: Oleksak, Patrik, et al.
Publicado: (2021)

Marine Invertebrate Peptides: Antimicrobial Peptides
por: Wu, Ran, et al.
Publicado: (2021)

Design, synthesis, and in vitro evaluation of BP-1-102 analogs with modified hydrophobic fragments for STAT3 inhibition
por: Oleksak, Patrik, et al.
Publicado: (2021)

Synergism of BCL-2 family inhibitors facilitates selective elimination of senescent cells
por: Rysanek, David, et al.
Publicado: (2022)

The oxazolomycin family: a review of current knowledge
por: Oleksak, Patrik, et al.
Publicado: (2020)

Distinct phenotypes and ‘bystander’ effects of senescent tumour cells induced by docetaxel or immunomodulatory cytokines
por: Sapega, Olena, et al.
Publicado: (2018)

Anti-NMDA receptor antibodies in patients with a first episode of schizophrenia
por: Masopust, Jiří, et al.
Publicado: (2015)

Dynamic PML protein nucleolar associations with persistent DNA damage lesions in response to nucleolar stress and senescence-inducing stimuli
por: Imrichova, Terezie, et al.
Publicado: (2019)

Chemistry and Toxicology of Major Bioactive Substances in Inocybe Mushrooms
por: Patocka, Jiri, et al.
Publicado: (2021)

Metformin: Activation of 5′ AMP-activated protein kinase and its emerging potential beyond anti-hyperglycemic action
por: Goel, Sanjay, et al.
Publicado: (2022)

Flakka: New Dangerous Synthetic Cathinone on the Drug Scene
por: Patocka, Jiri, et al.
Publicado: (2020)

Simvastatin Inhibits Endotoxin-Induced Apoptosis in Liver and Spleen Through Up-Regulation of Survivin/NF-κB/p65 Expression
por: Nežić, Lana, et al.
Publicado: (2019)

Plant Fortification of the Diet for Anti-Ageing Effects: A Review
por: Dhanjal, Daljeet Singh, et al.
Publicado: (2020)

Bioactive Compounds of Edible Fruits with Their Anti-Aging Properties: A Comprehensive Review to Prolong Human Life
por: Dhalaria, Rajni, et al.
Publicado: (2020)

Toxic Injury to Muscle Tissue of Rats Following Acute Oximes Exposure
por: Jaćević, Vesna, et al.
Publicado: (2019)

Acute Toxic Injuries of Rat’s Visceral Tissues Induced by Different Oximes
por: Jaćević, Vesna, et al.
Publicado: (2019)

Malus domestica: A Review on Nutritional Features, Chemical Composition, Traditional and Medicinal Value
por: Patocka, Jiri, et al.
Publicado: (2020)

Bacillus velezensis A2 Inhibited the Cecal Inflammation Induced by Zearalenone by Regulating Intestinal Flora and Short-Chain Fatty Acids
por: Cai, Jing, et al.
Publicado: (2022)

Tumor growth accelerated by chemotherapy-induced senescent cells is suppressed by treatment with IL-12 producing cellular vaccines
por: Simova, Jana, et al.
Publicado: (2016)

Improving the effectiveness of anti-aging modalities by using the constrained disorder principle-based management algorithms
por: Hurvitz, Noa, et al.
Publicado: (2022)

Applications of Fruit Polyphenols and Their Functionalized Nanoparticles Against Foodborne Bacteria: A Mini Review
por: Kumar, Harsh, et al.
Publicado: (2021)

Rapamycin reduces neuronal mutant huntingtin aggregation and ameliorates locomotor performance in Drosophila
por: Roth, Jonathan R., et al.
Publicado: (2023)

The Efficacy of Amifostine against Multiple-Dose Doxorubicin-Induced Toxicity in Rats
por: Jaćević, Vesna, et al.
Publicado: (2018)

The use of progeroid DNA repair-deficient mice for assessing anti-aging compounds, illustrating the benefits of nicotinamide riboside
por: Birkisdóttir, María B., et al.
Publicado: (2022)

Corrigendum: The use of progeroid DNA repair-deficient mice for assessing anti-aging compounds, illustrating the benefits of nicotinamide riboside
por: Birkisdóttir, María B., et al.
Publicado: (2022)

PRPF19 modulates morphology and growth behavior in a cell culture model of human skin
por: Kleissl, Lisa, et al.
Publicado: (2023)

An update on mobile applications collecting data among subjects with or at risk of Alzheimer's disease
por: Piendel, Lydia, et al.
Publicado: (2023)

A Review on the Synthesis and Bioactivity Aspects of Beauvericin, a Fusarium Mycotoxin
por: Wu, Qinghua, et al.
Publicado: (2018)

Type A Trichothecene Diacetoxyscirpenol-Induced Emesis Corresponds to Secretion of Peptide YY and Serotonin in Mink
por: Wu, Qinghua, et al.
Publicado: (2020)

Exploring the role of nanomedicines for the therapeutic approach of central nervous system dysfunction: At a glance
por: Rhaman, Md. Mominur, et al.
Publicado: (2022)

Novel Group of AChE Reactivators—Synthesis, In Vitro Reactivation and Molecular Docking Study
por: Malinak, David, et al.
Publicado: (2018)

The Significance of Reactive Oxygen Species and Antioxidant Defense System in Plants: A Concise Overview
por: Dumanović, Jelena, et al.
Publicado: (2021)

Effect Of An Extra-Virgin Olive Oil Intake On The Delay Of Cognitive Decline: Role Of Secoiridoid Oleuropein?
por: Klimova, Blanka, et al.
Publicado: (2019)

Melatonin as an Anti-Aging Therapy for Age-Related Cardiovascular and Neurodegenerative Diseases
por: Martín Giménez, Virna Margarita, et al.
Publicado: (2022)

Induction, regulation and roles of neural adhesion molecule L1CAM in cellular senescence
por: Mrazkova, Blanka, et al.
Publicado: (2018)

Patients with geriatric syndromes and anti-amyloid therapies: lack of consideration? An exploratory analysis of the literature
por: Sadlon, Angélique, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_d6om7tlffmqq9i6j2n8iu1402o