Constitutively active STING causes neuroinflammation and degeneration of dopaminergic neurons in mice

Stimulator of interferon genes (STING) is activated after detection of cytoplasmic dsDNA by cGAS (cyclic GMP-AMP synthase) as part of the innate immunity defence against viral pathogens. STING binds TANK-binding kinase 1 (TBK1). TBK1 mutations are associated with familial amyotrophic lateral scleros...

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Detalles Bibliográficos
Autores principales: Szego, Eva M, Malz, Laura, Bernhardt, Nadine, Rösen-Wolff, Angela, Falkenburger, Björn H, Luksch, Hella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9767458/
https://www.ncbi.nlm.nih.gov/pubmed/36314770
http://dx.doi.org/10.7554/eLife.81943

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9767458/
https://www.ncbi.nlm.nih.gov/pubmed/36314770
http://dx.doi.org/10.7554/eLife.81943

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