Inhibition of β1-AR/Gαs signaling promotes cardiomyocyte proliferation in juvenile mice through activation of RhoA-YAP axis

The regeneration potential of the mammalian heart is incredibly limited, as cardiomyocyte proliferation ceases shortly after birth. β-adrenergic receptor (β-AR) blockade has been shown to improve heart functions in response to injury; however, the underlying mechanisms remain poorly understood. Here...

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Detalles Bibliográficos
Autores principales: Sakabe, Masahide, Thompson, Michael, Chen, Nong, Verba, Mark, Hassan, Aishlin, Lu, Richard, Xin, Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9767473/
https://www.ncbi.nlm.nih.gov/pubmed/36479975
http://dx.doi.org/10.7554/eLife.74576

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9767473/
https://www.ncbi.nlm.nih.gov/pubmed/36479975
http://dx.doi.org/10.7554/eLife.74576

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