Discovery and mechanism studies of a novel ATG4B inhibitor Ebselen by drug repurposing and its anti-colorectal cancer effects in mice

Cysteine protease ATG4B, a key autophagy protein, is an attractive target for colorectal cancer therapy. However, ATG4B inhibitors with higher efficiency, safety, and clear mechanism are still limited. In this study, we discovered ATG4B inhibitors based on the FDA-approved drug library through FRET-...

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Detalles Bibliográficos
Autores principales: Xie, Huazhong, Qiang, Pengfei, Wang, Yao, Xia, Fan, Liu, Peiqing, Li, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9767854/
https://www.ncbi.nlm.nih.gov/pubmed/36539845
http://dx.doi.org/10.1186/s13578-022-00944-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9767854/
https://www.ncbi.nlm.nih.gov/pubmed/36539845
http://dx.doi.org/10.1186/s13578-022-00944-x

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