A single-cell atlas of glioblastoma evolution under therapy reveals cell-intrinsic and cell-extrinsic therapeutic targets

Recent longitudinal studies of glioblastoma (GBM) have demonstrated a lack of apparent selection pressure for specific DNA mutations in recurrent disease. Single-cell lineage tracing has shown that GBM cells possess a high degree of plasticity. Together this suggests that phenotype switching, as opp...

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Detalles Bibliográficos
Autores principales: Wang, Lin, Jung, Jangham, Babikir, Husam, Shamardani, Karin, Jain, Saket, Feng, Xi, Gupta, Nalin, Rosi, Susanna, Chang, Susan, Raleigh, David, Solomon, David, Phillips, Joanna J., Diaz, Aaron A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Resource
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9767870/
https://www.ncbi.nlm.nih.gov/pubmed/36539501
http://dx.doi.org/10.1038/s43018-022-00475-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9767870/
https://www.ncbi.nlm.nih.gov/pubmed/36539501
http://dx.doi.org/10.1038/s43018-022-00475-x

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