ADAMTSL3 knock-out mice develop cardiac dysfunction and dilatation with increased TGFβ signalling after pressure overload

Heart failure is a major cause of morbidity and mortality worldwide, and can result from pressure overload, where cardiac remodelling is characterized by cardiomyocyte hypertrophy and death, fibrosis, and inflammation. In failing hearts, transforming growth factor (TGF)β drives cardiac fibroblast (C...

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Detalles Bibliográficos
Autores principales: Rypdal, Karoline B., Olav Melleby, A., Robinson, Emma L., Li, Jia, Palmero, Sheryl, Seifert, Deborah E., Martin, Daniel, Clark, Catelyn, López, Begoña, Andreassen, Kristine, Dahl, Christen P., Sjaastad, Ivar, Tønnessen, Theis, Stokke, Mathis K., Louch, William E., González, Arantxa, Heymans, Stephane, Christensen, Geir, Apte, Suneel S., Lunde, Ida G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9767913/
https://www.ncbi.nlm.nih.gov/pubmed/36539599
http://dx.doi.org/10.1038/s42003-022-04361-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9767913/
https://www.ncbi.nlm.nih.gov/pubmed/36539599
http://dx.doi.org/10.1038/s42003-022-04361-1

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