Cargando…

ADAMTSL3 knock-out mice develop cardiac dysfunction and dilatation with increased TGFβ signalling after pressure overload

Heart failure is a major cause of morbidity and mortality worldwide, and can result from pressure overload, where cardiac remodelling is characterized by cardiomyocyte hypertrophy and death, fibrosis, and inflammation. In failing hearts, transforming growth factor (TGF)β drives cardiac fibroblast (C...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rypdal, Karoline B., Olav Melleby, A., Robinson, Emma L., Li, Jia, Palmero, Sheryl, Seifert, Deborah E., Martin, Daniel, Clark, Catelyn, López, Begoña, Andreassen, Kristine, Dahl, Christen P., Sjaastad, Ivar, Tønnessen, Theis, Stokke, Mathis K., Louch, William E., González, Arantxa, Heymans, Stephane, Christensen, Geir, Apte, Suneel S., Lunde, Ida G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9767913/ https://www.ncbi.nlm.nih.gov/pubmed/36539599 http://dx.doi.org/10.1038/s42003-022-04361-1

Ejemplares similares

The extracellular matrix glycoprotein ADAMTSL2 is increased in heart failure and inhibits TGFβ signalling in cardiac fibroblasts
por: Rypdal, Karoline B., et al.
Publicado: (2021)

Lumican accumulates with fibrillar collagen in fibrosis in hypertrophic cardiomyopathy
por: Rixon, Chloe, et al.
Publicado: (2022)

The extracellular matrix proteoglycan fibromodulin is upregulated in clinical and experimental heart failure and affects cardiac remodeling
por: Andenæs, Kine, et al.
Publicado: (2018)

Inflammation and Syndecan-4 Shedding from Cardiac Cells in Ischemic and Non-Ischemic Heart Disease
por: Strand, Mari E., et al.
Publicado: (2023)

Syndecan‐4 Protects the Heart From the Profibrotic Effects of Thrombin‐Cleaved Osteopontin
por: Herum, Kate M., et al.
Publicado: (2020)

Inhibition of the extracellular enzyme A disintegrin and metalloprotease with thrombospondin motif 4 prevents cardiac fibrosis and dysfunction
por: Vistnes, Maria, et al.
Publicado: (2023)

The Heparan Sulfate Proteoglycan Glypican-6 Is Upregulated in the Failing Heart, and Regulates Cardiomyocyte Growth through ERK1/2 Signaling
por: Melleby, Arne O., et al.
Publicado: (2016)

Adamtsl2 deletion results in bronchial fibrillin microfibril accumulation and bronchial epithelial dysplasia – a novel mouse model providing insights into geleophysic dysplasia
por: Hubmacher, Dirk, et al.
Publicado: (2015)

Cardiomyocyte-specific overexpression of syndecan-4 in mice results in activation of calcineurin-NFAT signalling and exacerbated cardiac hypertrophy
por: Lunde, Ida G., et al.
Publicado: (2022)

Impact of delayed type hypersensitivity arthritis on development of heart failure by aortic constriction in mice
por: Tønnessen, Theis Christian, et al.
Publicado: (2022)

Syndecan-4 Is Essential for Development of Concentric Myocardial Hypertrophy via Stretch-Induced Activation of the Calcineurin-NFAT Pathway
por: Finsen, Alexandra V., et al.
Publicado: (2011)

The female syndecan-4(−/−) heart has smaller cardiomyocytes, augmented insulin/pSer473-Akt/pSer9-GSK-3β signaling, and lowered SCOP, pThr308-Akt/Akt and GLUT4 levels
por: Støle, Thea Parsberg, et al.
Publicado: (2022)

An ADAMTSL2 Founder Mutation Causes Musladin-Lueke Syndrome, a Heritable Disorder of Beagle Dogs, Featuring Stiff Skin and Joint Contractures
por: Bader, Hannah L., et al.
Publicado: (2010)

Mechanism of Disease: Recessive ADAMTSL4 Mutations and Craniosynostosis with Ectopia Lentis
por: Gustafson, Jonas, et al.
Publicado: (2022)

The extracellular matrix proteoglycan lumican improves survival and counteracts cardiac dilatation and failure in mice subjected to pressure overload
por: Mohammadzadeh, Naiyereh, et al.
Publicado: (2019)

Secretogranin II; a Protein Increased in the Myocardium and Circulation in Heart Failure with Cardioprotective Properties
por: Røsjø, Helge, et al.
Publicado: (2012)

Sarcoplasmic Reticulum Calcium Release Is Required for Arrhythmogenesis in the Mouse
por: Edwards, Andrew G., et al.
Publicado: (2021)

Geleophysic dysplasia: novel missense variants and insights into ADAMTSL2 intracellular trafficking
por: Piccolo, Pasquale, et al.
Publicado: (2019)

Cooperative Mechanism of ADAMTS/ ADAMTSL and Fibrillin-1 in the Marfan Syndrome and Acromelic Dysplasias
por: Arnaud, Pauline, et al.
Publicado: (2021)

Pentosan Polysulfate Decreases Myocardial Expression of the Extracellular Matrix Enzyme ADAMTS4 and Improves Cardiac Function In Vivo in Rats Subjected to Pressure Overload by Aortic Banding
por: Vistnes, Maria, et al.
Publicado: (2014)

Etiology-Dependent Impairment of Diastolic Cardiomyocyte Calcium Homeostasis in Heart Failure With Preserved Ejection Fraction
por: Frisk, Michael, et al.
Publicado: (2021)

Germline variation in ADAMTSL1 is associated with prognosis following breast cancer treatment in young women
por: Kadalayil, Latha, et al.
Publicado: (2017)

The phenotypic spectrum of ADAMTSL4-associated ectopia lentis: Additional cases, complications, and review of literature
por: Knight, Lachlan S.W., et al.
Publicado: (2022)

A nonsense mutation in mouse Adamtsl2 causes uterine hypoplasia and an irregular estrous cycle
por: Iwanaga, Yuka, et al.
Publicado: (2023)

Exercise Training Stabilizes RyR2-Dependent Ca(2+) Release in Post-infarction Heart Failure
por: Danielsen, Tore Kristian, et al.
Publicado: (2021)

ADAMTSL4, a Secreted Glycoprotein, Is a Novel Immune-Related Biomarker for Primary Glioblastoma Multiforme
por: Zhao, Zheng, et al.
Publicado: (2019)

A de novo variant in the bovine ADAMTSL4 gene in an Original Braunvieh calf with congenital cataract
por: Häfliger, Irene M., et al.
Publicado: (2022)

Syndecan-4(–/–) Mice Have Smaller Muscle Fibers, Increased Akt/mTOR/S6K1 and Notch/HES-1 Pathways, and Alterations in Extracellular Matrix Components
por: Rønning, Sissel Beate, et al.
Publicado: (2020)

Exhausting treadmill running causes dephosphorylation of sMLC2 and reduced level of myofilament MLCK2 in slow twitch rat soleus muscle
por: Hortemo, Kristin Halvorsen, et al.
Publicado: (2015)

Regional diastolic dysfunction in post-infarction heart failure: role of local mechanical load and SERCA expression
por: Røe, Åsmund T, et al.
Publicado: (2019)

The oxidation‐resistant CaMKII‐MM281/282VV mutation does not prevent arrhythmias in CPVT1
por: Sadredini, Mani, et al.
Publicado: (2021)

Case report: A homozygous ADAMTSL2 missense variant causes geleophysic dysplasia with high similarity to Weill-Marchesani syndrome
por: Li, Mojiang, et al.
Publicado: (2022)

Elevated ventricular wall stress disrupts cardiomyocyte t-tubule structure and calcium homeostasis
por: Frisk, Michael, et al.
Publicado: (2016)

Compensatory and decompensatory alterations in cardiomyocyte Ca(2+) dynamics in hearts with diastolic dysfunction following aortic banding
por: Gattoni, Sara, et al.
Publicado: (2017)

Beta-Adrenoceptor Stimulation Reveals Ca(2+) Waves and Sarcoplasmic Reticulum Ca(2+) Depletion in Left Ventricular Cardiomyocytes from Post-Infarction Rats with and without Heart Failure
por: Sadredini, Mani, et al.
Publicado: (2016)

Increased Levels of Eotaxin and MCP-1 in Juvenile Dermatomyositis Median 16.8 Years after Disease Onset; Associations with Disease Activity, Duration and Organ Damage
por: Sanner, Helga, et al.
Publicado: (2014)

Generation of a novel mouse strain with fibroblast-specific expression of Cre recombinase
por: Alam, Jahedul, et al.
Publicado: (2020)

Attenuated Fatigue in Slow Twitch Skeletal Muscle during Isotonic Exercise in Rats with Chronic Heart Failure
por: Munkvik, Morten, et al.
Publicado: (2011)

Ryanodine receptor dispersion disrupts Ca(2+) release in failing cardiac myocytes
por: Kolstad, Terje R, et al.
Publicado: (2018)

Lack of Chemokine Signaling through CXCR5 Causes Increased Mortality, Ventricular Dilatation and Deranged Matrix during Cardiac Pressure Overload
por: Waehre, Anne, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_qou0b8m61uitvtm84an02lbgsv