Niacin exacerbates β cell lipotoxicity in diet-induced obesity mice through upregulation of GPR109A and PPARγ2: Inhibition by incretin drugs

The widely used lipid-lowering drug niacin was reported to increase blood glucose in diabetes. How does niacin regulate β Cell function in diabetic patients remains unclear. This study aimed to investigate the effect of niacin on β cell lipotoxicity in vitro and in vivo. Niacin treatment sensitized...

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Detalles Bibliográficos
Autores principales: Zhang, Xiaojing, Zhu, Baoyi, Lin, Peibin, Liu, Xiaoping, Gao, Jun, Yin, Dazhong, Zeng, Jianwen, Liao, Baojian, Kang, Zhanfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768175/
https://www.ncbi.nlm.nih.gov/pubmed/36568082
http://dx.doi.org/10.3389/fendo.2022.1057905

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768175/
https://www.ncbi.nlm.nih.gov/pubmed/36568082
http://dx.doi.org/10.3389/fendo.2022.1057905

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