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Might nontransferrin-bound iron in blood plasma and sera be a nonproteinaceous high-molecular-mass Fe(III) aggregate?
The HFE (Homeostatic Fe regulator) gene is commonly mutated in hereditary hemochromatosis. Blood of (HFE)(−/−) mice and of humans with hemochromatosis contains toxic nontransferrin-bound iron (NTBI) which accumulates in organs. However, the chemical composition of NTBI is uncertain. To investigate,...
Autores principales: | Vali, Shaik Waseem, Lindahl, Paul A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768373/ https://www.ncbi.nlm.nih.gov/pubmed/36334631 http://dx.doi.org/10.1016/j.jbc.2022.102667 |
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