Rate of transcription elongation and sequence-specific pausing by RNA polymerase I directly influence rRNA processing

One of the first steps in ribosome biogenesis is transcription of the ribosomal DNA by RNA polymerase I (Pol I). Processing of the resultant rRNA begins cotranscriptionally, and perturbation of Pol I transcription elongation results in defective rRNA processing. Mechanistic insight regarding the lin...

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Detalles Bibliográficos
Autores principales: Huffines, Abigail K., Engel, Krysta L., French, Sarah L., Zhang, Yinfeng, Viktorovskaya, Olga V., Schneider, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768379/
https://www.ncbi.nlm.nih.gov/pubmed/36423683
http://dx.doi.org/10.1016/j.jbc.2022.102730

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768379/
https://www.ncbi.nlm.nih.gov/pubmed/36423683
http://dx.doi.org/10.1016/j.jbc.2022.102730

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