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Rate of transcription elongation and sequence-specific pausing by RNA polymerase I directly influence rRNA processing
One of the first steps in ribosome biogenesis is transcription of the ribosomal DNA by RNA polymerase I (Pol I). Processing of the resultant rRNA begins cotranscriptionally, and perturbation of Pol I transcription elongation results in defective rRNA processing. Mechanistic insight regarding the lin...
Autores principales: | Huffines, Abigail K., Engel, Krysta L., French, Sarah L., Zhang, Yinfeng, Viktorovskaya, Olga V., Schneider, David A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768379/ https://www.ncbi.nlm.nih.gov/pubmed/36423683 http://dx.doi.org/10.1016/j.jbc.2022.102730 |
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