Bmpr2 mutant mice are an inadequate model for studying iron deficiency in pulmonary hypertension

As bone morphogenetic protein receptor type II (Bmpr2) mutations are the most common genetic cause of pulmonary arterial hypertension (PAH), and iron deficiency (ID) is associated with worse clinical outcomes in PAH patients, we proposed to use Bmpr2 ± mice to induce a model of ID in pulmonary vascu...

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Autores principales: Zhang, Vida, Ganz, Tomas, Nemeth, Elizabeta, Umar, Soban, Kim, Airie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Letters
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768458/
https://www.ncbi.nlm.nih.gov/pubmed/36568690
http://dx.doi.org/10.1002/pul2.12151
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author Zhang, Vida
Ganz, Tomas
Nemeth, Elizabeta
Umar, Soban
Kim, Airie
author_facet Zhang, Vida
Ganz, Tomas
Nemeth, Elizabeta
Umar, Soban
Kim, Airie
author_sort Zhang, Vida
collection PubMed
description As bone morphogenetic protein receptor type II (Bmpr2) mutations are the most common genetic cause of pulmonary arterial hypertension (PAH), and iron deficiency (ID) is associated with worse clinical outcomes in PAH patients, we proposed to use Bmpr2 ± mice to induce a model of ID in pulmonary vascular disease. Our study shows that these transgenic mice are not a good model for this clinical phenomenon.
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spelling pubmed-97684582022-12-23 Bmpr2 mutant mice are an inadequate model for studying iron deficiency in pulmonary hypertension Zhang, Vida Ganz, Tomas Nemeth, Elizabeta Umar, Soban Kim, Airie Pulm Circ Research Letters As bone morphogenetic protein receptor type II (Bmpr2) mutations are the most common genetic cause of pulmonary arterial hypertension (PAH), and iron deficiency (ID) is associated with worse clinical outcomes in PAH patients, we proposed to use Bmpr2 ± mice to induce a model of ID in pulmonary vascular disease. Our study shows that these transgenic mice are not a good model for this clinical phenomenon. John Wiley and Sons Inc. 2022-10-01 /pmc/articles/PMC9768458/ /pubmed/36568690 http://dx.doi.org/10.1002/pul2.12151 Text en © 2022 The Authors. Pulmonary Circulation published by Wiley Periodicals LLC on behalf of the Pulmonary Vascular Research Institute. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Research Letters
Zhang, Vida
Ganz, Tomas
Nemeth, Elizabeta
Umar, Soban
Kim, Airie
Bmpr2 mutant mice are an inadequate model for studying iron deficiency in pulmonary hypertension
title Bmpr2 mutant mice are an inadequate model for studying iron deficiency in pulmonary hypertension
title_full Bmpr2 mutant mice are an inadequate model for studying iron deficiency in pulmonary hypertension
title_fullStr Bmpr2 mutant mice are an inadequate model for studying iron deficiency in pulmonary hypertension
title_full_unstemmed Bmpr2 mutant mice are an inadequate model for studying iron deficiency in pulmonary hypertension
title_short Bmpr2 mutant mice are an inadequate model for studying iron deficiency in pulmonary hypertension
title_sort bmpr2 mutant mice are an inadequate model for studying iron deficiency in pulmonary hypertension
topic Research Letters
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768458/
https://www.ncbi.nlm.nih.gov/pubmed/36568690
http://dx.doi.org/10.1002/pul2.12151
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