SIRT1 haplo-insufficiency results in reduced cortical bone thickness, increased porosity and decreased estrogen receptor alpha in bone in adult 129/Sv female mice

INTRODUCTION: Sirtuin 1 (SIRT1) is a key player in aging and metabolism and regulates bone mass and architecture. Sexual dimorphism in skeletal effects of SIRT1 has been reported, with an unfavorable phenotype primarily in female mice. METHODS: To investigate the mechanisms of gender differences in...

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Detalles Bibliográficos
Autores principales: Artsi, Hanna, Cohen-Kfir, Einav, Shahar, Ron, Kalish-Achrai, Noga, Lishinsky, Natan, Dresner-Pollak, Rivka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768543/
https://www.ncbi.nlm.nih.gov/pubmed/36568088
http://dx.doi.org/10.3389/fendo.2022.1032262

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768543/
https://www.ncbi.nlm.nih.gov/pubmed/36568088
http://dx.doi.org/10.3389/fendo.2022.1032262

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