CBL0137 impairs homologous recombination repair and sensitizes high-grade serous ovarian carcinoma to PARP inhibitors

BACKGROUND: High-grade serous ovarian carcinomas (HGSCs) are a heterogeneous subtype of epithelial ovarian cancers and include serous cancers arising in the fallopian tube and peritoneum. These cancers are now subdivided into homologous recombination repair (HR)-deficient and proficient subgroups as...

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Detalles Bibliográficos
Autores principales: Lu, Xue, He, Yaowu, Johnston, Rebecca L., Nanayakarra, Devathri, Sankarasubramanian, Sivanandhini, Lopez, J. Alejandro, Friedlander, Michael, Kalimutho, Murugan, Hooper, John D., Raninga, Prahlad V., Khanna, Kum Kum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9769062/
https://www.ncbi.nlm.nih.gov/pubmed/36539830
http://dx.doi.org/10.1186/s13046-022-02570-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9769062/
https://www.ncbi.nlm.nih.gov/pubmed/36539830
http://dx.doi.org/10.1186/s13046-022-02570-4

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