Structural Studies Reveal that Endosomal Cations Promote Formation of Infectious Coxsackievirus A9 A-Particles, Facilitating RNA and VP4 Release

Coxsackievirus A9 (CVA9), an enterovirus, is a common cause of pediatric aseptic meningitis and neonatal sepsis. During cell entry, enterovirus capsids undergo conformational changes leading to expansion, formation of large pores, externalization of VP1 N termini, and loss of the lipid factor from V...

Descripción completa

Detalles Bibliográficos
Autores principales: Domanska, Aušra, Plavec, Zlatka, Ruokolainen, Visa, Löflund, Benita, Marjomäki, Varpu, Butcher, Sarah J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Structure and Assembly
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9769374/
https://www.ncbi.nlm.nih.gov/pubmed/36448797
http://dx.doi.org/10.1128/jvi.01367-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9769374/
https://www.ncbi.nlm.nih.gov/pubmed/36448797
http://dx.doi.org/10.1128/jvi.01367-22

Ejemplares similares