Redox Cycling Dioxonaphthoimidazoliums Disrupt Iron Homeostasis in Mycobacterium bovis Bacillus Calmette-Guérin

The dioxonaphthoimidazolium scaffold is a novel, highly bactericidal redox cycling antituberculosis chemotype that is reliant on the respiratory enzyme Type II NADH dehydrogenase (NDH2) for the generation of reactive oxygen species (ROS). Here, we employed Mycobacterium bovis Bacillus Calmette-Guéri...

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Detalles Bibliográficos
Autores principales: Li, Ming, Yamada, Yoshiyuki, Rodriguez, G. Marcela, Dick, Thomas, Go, Mei Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9769636/
https://www.ncbi.nlm.nih.gov/pubmed/36377959
http://dx.doi.org/10.1128/spectrum.01970-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9769636/
https://www.ncbi.nlm.nih.gov/pubmed/36377959
http://dx.doi.org/10.1128/spectrum.01970-22

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